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There are no contraindications to oral administration of acetylcysteine in the treatment of acetaminophen overdose

the localized acidic environment (pH=5.5-6.5) prevents transmembrane transport of weakly alkaline drugs

Along this line of thought, it has been suggested that positively affecting the redox potential might benefit aspects neurologic functioning in the short term and may hold promise to contribute to attenuation of neurodegenerative processes that occur in MS over the longer term ( Glutathione is the principle naturally occurring antioxidant in neurons which protects against oxidative damage

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Early trials reported it to be generally well tolerated at low doses, but these studies were small and of short duration