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coli : Escherichia coli eIF2: Eukaryotic initiation factor 2 alpha GDH: Glutamate dehydrogenase GLS: Glutaminase GLS1: Kidney-type glutaminase HCC: Hepatocellular carcinoma Hsp60: Heat shock protein 60 IDH: Isocitrate dehydrogenase MSC: Mesenchymal stromal cells mTORC1: Mammalian target of rapamycin complex 1 NO: Nitric oxide NOD-SCID mouse: Non-obsese diabetes severe combined immune-deficiency mouse NOS: Nitric oxide synthases NOS: Nitroc oxide synthase ODC: Ornithine decarboxylase OTC: Ornithine transcarbamylase pegylated arginase I: Peg-arg I PI3K-Akt Pathway: Phosphatidylinositol 3-kinase-protein kinase B pathway s.c.: Sub-cutaneous injection SLC1A5/38A2: Solute carrier family 1 member 5/38A2 T- ALL: T-lineage acute lymphoblastic leukemia TCA cycle: Tricarboxylic acid cycle TORC1: Target of rapamycin complex 1 TORC2: Target of rapamycin complex 2 -FBP: (R)-gamma-(2-fluoro-benzyl)-L-proline References Hanahan D, Weinberg RA

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