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A 2026 study (PMID 41418663) used IGF-1 LR3 as the therapeutic agent in a rat volumetric muscle loss (VML) model, delivering the peptide via poly(lactic-co-glycolic acid) microencapsulation within a polyethylene glycol-acrylate hydrogel void filler

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In this regard, pro-inflammatory cytokines may account for the loss of muscle mass by activating catabolic and downregulating the anabolic pathways [75]