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For instance, the novel triterpenoid methyl CDDO derivative (CDDO-Me) potently induced cytotoxicity in imatinib-resistant myeloid leukemia cells, accompanied by a rapid and selective depletion of mGSH resulting in increased generation of ROS and mitochondrial dysfunction (Samudio et al., 2005, 2008)

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The role of thyroid diseases and anti-TPO and anti-Tg antibodies in the development of breast cancer has been investigated in numerous studies with still controversial results