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Supporting the clinical relevance of these findings, the expression of CTR1, ATP7A and ABCG2 has been reported to have predictive value in the response to platinum-based chemotherapy and patient prognosis in tobacco-associated cancers 48,49,50

Nearly all participants reported increased stress related to COVID-19 namely, fears about the virus, job uncertainty, and the psychological effects of isolation and described this as the primary driver of increased nicotine and tobacco use

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