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However, it's worth noting that this study was observational and does not prove cause and effect

Knockout of the mitochondrial calcium uniporter strongly suppresses stimulus-metabolism coupling in pancreatic acinar cells but does not reduce severity of experimental acute pancreatitis

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It is yet to be determined whether these different assembly states respond to specific cellular signals, facilitate the recognition of distinct substrates, or play a role in assembling with the CULLIN4-RBX1 complex

Co-formulation does not affect the stability of the components: the ratios are optimized to ensure chemical compatibility between the peptides in the same vial