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[DOI] [PubMed] [Google Scholar] 25.Safarinejad MR

[DOI] [PMC free article] [PubMed] [Google Scholar] 197.Petersen A.C., McKenna M.J., Medved I., Murphy K.T., Brown M.J., Della Gatta P., Cameron-Smith D

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LH/FSH dysregulation an elevated LH-to-FSH ratio produced by abnormally rapid GnRH pulse frequency in the hypothalamus, creating a hormonal environment that stimulates androgen production while suppressing follicle maturation.[3] Chronic low-grade inflammation elevated CRP, IL-6, and TNF-, even in lean women with PCOS and in the absence of obesity, suggesting that inflammation is a core feature, not a secondary consequence of excess weight