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Bone morphogenetic proteins (BMPs) are the most representative example, which have been granted US Food and Drug Administration (FDA) approval for clinical applications in recalcitrant long bone non-unions, lumbar fusion and open tibial shaft fractures [1618]
Certain investigations have noted patterns of initial arousal followed by sedation, suggesting complex interactions with sleep architecture
Research has also explored its effects on the repair of musculoskeletal structures including tendons and ligaments, with studies examining cell migration and collagen organisation in damaged tissue models
Experimental studies have proposed several pathways: changes in nitric-oxide signalling and blood-vessel function
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