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Therefore, it is continuously synthesized throughout the human body (Figure 1)

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However, some healthcare providers recommend retesting at 3-6 months, 12 months, and annually as part of a wellness screen

The reduction of IIS in Laron subjects unmasks the potential role of persistent hyperactive IIS mediated by Western diet in the development of diseases of civilization and offers a rational perspective for dietary adjustments with less insulinotropic diets like the Paleolithic diet