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Effect of nicotine on various key metabolic processes While it is now reasonably well established that the use of tobacco is a major health hazard [4,5], the World Health Organization estimates that about one billion of the worlds population still continue to use various tobacco products including the now more popular smokeless varieties despite the numerous deleterious effects they have on the human body [6]

These gums provide a low and controlled dose of nicotine to help individuals reduce their tobacco urges

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Metcalfe et al [133] found that cigarette smoke extract inhibited the responses of COPD-derived alveolar macrophages to TLR signaling and Haemophilus influenza stimulation

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