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3.3 Immune system enhancement The natural substances can act as immune checkpoint and co-inhibitory modulators, some polyphenols decrease the expression of tissue-and tumoural PD-L1 or of CTLA-4 on T cells giving a mechanistic reasoning to combination with nutritional support in patients treated with check point inhibitors, eventually reversing acquired resistance to treatment or decreasing the effective dose for drug administration (193)

Refrigerated storage following reconstitution

Every 10C temperature reduction approximately halves the rate of most chemical degradation reactions

Those With Bleeding Disorders: Animal studies suggesting enhanced blood vessel formation and circulation effects warrant caution in individuals with bleeding disorders or taking anticoagulant medications

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