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Its effects have been linked to endothelial nitric-oxide synthase (eNOS) and to VEGFR2-driven angiogenesis, and its influence on fibroblast outgrowth and migration is attributed to the FAKpaxillin signaling pathway

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Patients who have early Leber's disease (hereditary optic nerve atrophy) have been found to suffer severe and swift optic atrophy when treated with vitamin B12

The dopaminergic effects may also play a role

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