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89 When mitochondrial fusion is suppressed by the down-regulation of OPA1, resulting in elevated ROS levels while an decrease in antioxidant enzyme levels, finally contributing to oxidative stress and cellular damage

Oxidative Stress in Neurodegeneration: Cause or Consequence

In CRC or glioma cell lines, NAMPT functions to increase NADH pools, protecting cells against oxidative stress

Akita K, Isoda K, Shimada K, Daida H (2015) Dipeptidyl-peptidase-4 inhibitor, alogliptin, attenuates arterial inflammation and neointimal formation after injury in low-density lipoprotein (LDL) receptor-deficient mice

BMJ 379, e072385