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Substantive review of a PMTA, for example, includes a multi-disciplinary review of a products engineering, chemistry, toxicology, behavioral and clinical pharmacology, microbiology, individual health impact, and population health impact

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Spliffs offer easier rolling, more consistent burning, and a unique nicotine-cannabis combination, while joints provide pure cannabis effects without tobaccos health risks or addiction potential

Cigarette smoking remains one of the most significant health hazards globally, directly linked to millions of deaths annually due to its addictive nature, frequency, and deep inhalation practices

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