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Bipolar Disord 14:478487

However, a breakthrough came with the observation that TICs, rather than the bulk of differentiated tumor cells, thrive in 3D gels [23, 24], offering an opportunity to uncover signaling pathways specific to TIC growth and identify TIC-specific therapeutic targets

Further proteomic analysis of the epididymis and sperm revealed that proteins essential in metabolism, ROS production, stress, inflammation and in the regulation of reproductive function were adversely affected

Hail N, Carter BZ, Konopleva M, Andreeff M

4a, centre), which has the overall effect of disrupting mitochondrial membranes