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The real research question is not "which one wins," but "what happens when we combine the two approaches?" This is the purpose of CagriSema and REDEFINE trials

Stacked on top of insulin or a sulfonylurea it can, and the lever is de-intensifying that background drug, not lowering the tirzepatide dose. Over-loss in low-BMI deep responders Across the obesity trials, about 7% of participants fell below a BMI of 22, some by week 12