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The interneuron energy hypothesis: Implications for brain disease

Statins reduce CoQ10 levels via depressing the HMG-CoA activity to inhibition of the mevalonate pathway impairing mitochondrial electron transport chain and ATP production

Bachelez H, van de Kerkhof PC, Strohal R, Kubanov A, Valenzuela F, Lee JH,

Excess and chronic consumption of methionine-rich meals overutilizes this metabolic pathway, resulting in excess reactive oxygen species (ROS) production