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Routine Prophylaxis Study In a multicenter, open-label, prospective, randomized, controlled postmarketing clinical trial of ADVATE use in two prophylactic treatment regimens compared to that of on-demand treatment, 53 PTPs with severe to moderately severe hemophilia A (FVIII level 2 IU/dL) were analyzed in the per-protocol group

Right heart failure is associated with venous stasis and thrombosis that may result in pulmonary embolism and further compromise the pulmonary circulation

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Hunt KK, McBride WH, Toloza E, Swisher SG , Rhoades KL, Drake TA, Economou JS