Human data remain limited and mixed, with dose, timing, and sex as key variables
We should pull
[DOI] [PMC free article] [PubMed] [Google Scholar] 40.Witschi A., Reddy S., Stofer B., Lauterburg B.H
For example, ALS presents both sporadic and familial forms, often linked to defective DNA repair, which leads to neuronal damage, premature aging, and subsequent neurodegeneration ( 2.5 Ferroptosis in neurodegenerative pathogenesis Iron is the most abundant transition metal in the human brain and participates in vital CNS functions such as mitochondrial energy transduction, enzymatic catalysis, myelination, synaptic plasticity, and neurotransmitter synthesis and degradation ( Figure 1
Health Perspect.,2001 111