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Another significant concern is that excessive modulation of the Th17/Treg balance carries potential risks, as it may damage the hosts immune defense against pathogens or destroy self-tolerance

Diabetes, Obesity and Metabolism , 22(9), 1454-1467

PMID: 21602659

Patient selection should prioritize individuals with conditions where established therapies have proven inadequate or are contraindicated

Abstract Background Exercise induces changes in several organs and tissues, and this process might be due to oxidative damage caused by free radicals and inflammatory mediators