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Research has also examined its role in circadian rhythm signaling and melatonin-related pathways , which are central to sleepwake regulation and endocrine timing in experimental systems

Aging leads to altered microglial function that reduces brain resiliency increasing vulnerability to neurodegenerative diseases

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Given the essential role of neurotrophic factors in neuronal plasticity and function, a significant number of psychiatric and neurodegenerative disorders are associated with altered neurotrophic factors levels and expression of their cognate receptors [25, 30, 31]

Insulin-like Growth Factor-1 Long R3 is a modified IGF-1 with an extended half-life