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For tobacco and marijuana smoke, respectively, 4350 and 2575 different compounds are detected, of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms

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The secret and soul of Marlboro: Phillip Morris and the origins, spread, and denial of nicotine freebasing Am J Public Health

It's really hard, because the setting is the most important thing

However, this effect is only temporary as smoking can lead to low T in the long run by negatively impacting overall health