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Under normal physiological conditions, nuclear factor erythroid 2-related factor 2 (Nrf2) remains sequestered in the cytoplasm through its association with Kelch-like ECH-associated protein 1 (Keap1)

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American Journal of Clinical Nutrition 80, 16111617 [DOI] [PubMed] [Google Scholar] James S.J., Melnyk S., Jernigan S., Cleves M.A., Halsted C.H., Wong D.H

Furthermore, elevated glutathione synthesis in TLS in the kidney is reflected in urinary GSH concentration, suggesting the possibility of its clinical application as a novel biomarker to detect TLS in the kidney