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Clinically, kisspeptin is very well tolerated and can reinitiate pulsatile LH secretion in women with hypothalamic amenorrhea, so it will be applicable where low GnRH drive is the underlying cause

doi: 10.1096/fj.201600293r 32 ChenYYangYLiuZHeL

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PT-141 (Bremelanotide) is a melanocortin receptor agonist that acts centrally on arousal pathways in the brain