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Introduction Amodiaquine is a potent anti-malaria drug, however, rare but life-threatening idiosyncratic hepatotoxicity (1/15,500 patients) and agranulocytosis (1/2000 patients) have restricted its therapeutic use (Olliaro and Mussano, 2003

While agar-based nanoparticle systems are still emerging in BBB research, several universal design principles apply: These parameters are critical in adapting established ligand systems to agar-based nanoparticle platforms

Typically, within the activation step, the metal-halide bond is cleaved, and the open coordination site of the metal complex is used for electron or proton transfer reactions

The recombinant mutants K26A and D90A were subsequently purified (Supplementary Fig

In Parkinson's disease, NRF2 agonists (such as simvastatin) enhance the neuronal antioxidant capacity by upregulating antioxidant enzyme levels, thereby reducing ROS-induced apoptosis [219]