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Cannabinoid receptors 2-AG is a high-efficacy agonist of the CB1 and CB2 with K i values of 472 nM and 1400 nM, whereas AEA is a very low-efficacy agonist for CB1 and a low-efficacy agonist for CB2 receptors with K i values of 5810 nM and 1930 nM, respectively [58, 59]