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High doses of B12 may worsen the disease and cause irreversible damage to the optic nerve

The compound appears to work by increasing intracellular NAD+ levels (through preventing nicotinamide consumption by NNMT), which activates sirtuins and enhances mitochondrial function and fatty acid oxidation, while also promoting a phenomenon called "browning" of white adipose tissue - the transformation of energy-storing white fat cells into metabolically active beige/brown adipocytes that burn fatty acids for thermogenesis rather than storing them

The quality of this powder is paramount

So far, however, there is no scientific documentation or research on this subject, which is why it is currently not possible to make any claims here

Always titrate from the lowest dose to manage GI tolerability