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Exercise reverses aging clocks in human study

NSAIDs also have harmful effects on the liver, kidneys, GI tract and cardiovascular system, while steroids can affect blood sugar levels and cause weight gain, exacerbating metabolic issues that contribute to knee OA

Those who experienced severe GI side effects on tirzepatide or semaglutide that required treatment discontinuation should proceed with extreme caution, as the combination will likely produce similar or potentially more pronounced effects

Additionally, some worry about the drug being abused by patients taking it recreationally for cosmetic purposes with no official metabolic work up

Phase 3 (1.0 mg x 4 weeks) uses 4 mg total