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Physiological fatigue corresponds to a homeostatic process, selected by evolution for its usefulness, whereas pathological fatigue unravels a dyshomeostatic state, which reflects a combined dysfunctioning of numerous potential systems, revealed by both physiological issues (chronic inflammation, mitochondrial dysfunctioning, cardio-pulmonary pathologies, endocrinopathies, vitamin deficiencies) and interoceptive processes, with inappropriate corrections by the brain of biological perturbations

MRI scans were performed using a T1w volumetric fast spoiled gradient echo (FSPGR) sequence (slice thickness = 1.5 mm, repetition time = 33.33 ms, echo time = 6 ms, flip angle = 35)

In photographic documentation, patients often appear fresher, more rested, and subtly rejuvenated