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Most patients begin noticing changes within 46 weeks, with more visible results after 812 weeks

The beneficial effect of coenzyme Q10 has been assigned to its antioxidant and inflammatory properties

In controlled lab settings investigators have reported minimal acute toxicity during experimental protocols but researchers emphasize the importance of proper handling and safety protocols

Theoretically, this could result in increased fractional oxidation and an increased propensity to toxicity (see Fig

It has been reported that when ferroptosis occurs in neurons, then microglia are activated and release toxic substances including pro-inflammatory factor IL-6, which can cause neuro-inflammation and lead to further brain damage (Tang et al., 2020)