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The solution formulations use propylene glycol as a vehicle, which can cause scalp irritation in sensitive individuals

A diagnosis of primary carnitine deficiency requires that serum, red cell and/or tissue carnitine levels be low and that the patient does not have a primary defect in fatty acid or organic acid oxidation (see Clinical Pharmacology)

Ingestion of 4 g synthetic carnosine alone by adult humans does not affect its concentrations in plasma due to high carnosinase-1 activity in plasma that rapidly hydrolyzes carnosine into -alanine and histidine, but does increase the urinary output of carnosine (Gardner et al

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Production declines with age