lipo c vs mots c MOTS-c: A promising mitochondrial-derived peptide for therapeutic exploitation MOTS-C Peptide: Benefits, Mechanism, Safety,

Tabe Y, Jin L, Kazuno S, Fujimura T, Matsushit H, Ueno T, Miida T, Andreeff M , Gutterman JU, Konopleva M

17,18,19,20,21 This increase in synaptic glutamate occurs because of decreased tone and function of the extrasynaptic metabotropic glutamate autoreceptors, mGluR2/3, which normally inhibits synaptic glutamate release (this decreased inhibition leads to increased synaptic glutamate) 17,20 and decreased function of glial glutamate transporter-1, which causes reduced glutamate elimination from extracellular space resulting in spillover of synaptic glutamate

Anyone considering these compounds should seek advice from a qualified healthcare professional rather than relying on unregulated products or anecdotal claims

R.BlochM.GimonaA.et al (2012)

It acts as a front-line defence in the intestinal mucosa, breaking down histamine present in food or produced by gut microbes before it can trigger unwanted symptoms elsewhere in the body