aod9604 effects on appetite Obesity Pharmacotherapy: Current Perspectives and Future Directions Stubborn fat that just won't

Preclinical research suggests NNMT inhibition may affect fat cell metabolism, insulin sensitivity, body weight, and energy expenditure in animal or cell models

Heavier individuals may require higher doses to achieve equivalent NNMT inhibition due to larger adipose tissue mass and potentially higher baseline NNMT activity

Oral dosing ranges discussed in research community use Phase Weeks 12 (start low) Daily dose 50 mg once daily Notes Morning dosing is the pattern most often reported

Metabolic Flexibility Enhancement: 5-Amino-1MQ promotes metabolic flexibility, the ability to efficiently switch between burning carbohydrates and fats for fuel

Potential side effects are minimal in studies, but include mild gastrointestinal issues