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Previously, we reported that pheomelanin synthesis promotes melanoma formation in a UV radiation-independent context along with significantly higher oxidative DNA and lipid peroxidation damage in Mc1r deficient, red-haired mice compared to genetically matched black ( Mc1r -wildtype), albino, or combination red-albino mice 5

We found that, as with folate deficiency (which may effectively alter methylation reactions and deoxyribonucleotide biosynthesis), methionine loading (which maintains an efficient transmethylation pathway) promotes the occurrence of an oxidant stress-mediated prethrombotic state that is correlated with total plasma homocysteine concentration (Durand et al, 1997a