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As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

However, the expression of the Ptgs2os2 gene, which encodes LincRNA-Cox-2, a positive regulator of Ptgs2 expression and general inflammation 30 , differed between these cell lines, being increased in sensitized relative to resolved differentiated urothelia

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