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These topical agents have not been adequately evaluated for safety and efficacy in pregnant patients

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Furthermore, several studies and reports have indicated the benefit of capecitabine in treating advanced or recurrent head and neck SCC (240)

While G6PD deficiency induced hemolytic anemia can cause hypoxia due to nonfunctioning, hemolyzed erythrocytes, it is important to also monitor the patient for methemoglobinemia