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Carotenoids in human skin In vivo : antioxidant and photo-protectant role against external and internal stressors
(40)directly demonstrated LPARs importance: LPAR1 expresses in LPA (18:1)-responsive, androgen-insensitive PCa cells but not in androgen-dependent LNCaP cells (unresponsive to LPAs proliferative effects)
Review criteria Relevant studies published between January 1, 2000, and January 1, 2023, were identified from PubMed, EMBASE, Cochrane Library and the ClinicalTrials.gov registry, using the search terms Graves disease treatment, Graves disease therapy, Graves disease management, Graves disease pathogenesis, Graves orbitopathy, Graves ophthalmopathy, thyroid eye disease, thyroid-associated ophthalmopathy, thyroid ophthalmopathy, endocrine ophthalmopathy
Neither addresses the cellular repair mechanisms that keep follicles healthy and functioning