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Increased inflammatory response in long-term CSE exposed cells To investigate whether these mitochondrial changes induced by long-term CSE exposure were accompanied by increased pro-inflammatory activity of bronchial epithelium, we measured expression of the pro-inflammatory cytokines IL-1, IL-6 and IL-8, which are known to be elevated in the airways of COPD patients [34, 35]

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These analyses confirmed an association, but also found that the strength of the apparently causal association between e-cigarette use and smoking was similar to that between smoking and e-cigarette use

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" The record feels brutal ," admits Gonzalez