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The path forward For 5-amino-1mq to move from research compound to established therapy, human clinical trials are needed
Aydin 1 , Adam Hilbert 1 , Charles Majoie 3 , Wim Van Zwam 4 , Aad van der Lugt 5 , Peter Vajkoczy 2 , Dietmar Frey 1,2 1 CLAIM - Charit Lab for Artificial Intelligence in Medicine,Charit Universittsmedizin Berlin, Berlin, Germany, 2 Department of Neurosurgery, Charit Universittsmedizin Berlin, Berlin, Germany, 3 Department of Radiology and Nuclear Medicine, Amsterdam UMC, Amsterdam, Netherlands, 4 Department of Radiology and Nuclear Medicine, Maastricht University Medical Centre, Maastricht, Netherlands, 5 Department of Radiology and Nuclear Medicine, Erasmus MC, Rotterdam, Netherlands Background and Aims: A major determinant in individual functional outcomes following a large vessel occlusion (LVO) stroke is the degree of collateral circulation
Standard beginner protocols typically involve 1-2 mg administered subcutaneously 2-3 times per week, with most researchers running 8-12 week cycles followed by 4-6 week breaks
Additionally, sleeping with the head slightly elevated (4-6 inches) can reduce the frequency of nighttime reflux episodes
