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discovered that Apoptosis-Inducing Factor Mitochondria-Associated 2(AIFM2) can reduce cellular sensitivity to iron-dependent cell death by decreasing Coenzyme Q10 (CoQ10) level, thereby exhibiting an anti-ferroptotic effect independent of GPX4 (106)

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152,153 Minority mitochondrial outer membrane permeabilization (miMOMP) normally occurs in senescent cells, enhances the secretion of mtDNA into the cytoplasm and stimulates the cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway to promote SASP