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The tumor volume was monitored through imaging using an IVIS Spectrum system (PerkinElmer) at 0-day, 4-day, 8-day, and 12-day postinjection, respectively (100 L luciferinper mouse, 15 mg ml 1 )

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Therefore, the data were analyzed with a piecewise approach to compare the rate of regeneration within the first half (112 weeks) and compare the extent of regeneration in the latter half (1224 weeks) of the study period

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