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As reported, NLRP3 inflammasome activation plays a key role in defence against pathogens, and the mitochondria-related E3 ligase MARCH5 can interact with the NACHT domain of NLRP3 inflammasomes to mediate inflammasome activation (69)

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6 S0 applies to pharmacological substances that are not addressed by another section of the List and do not have current approval by a governmental regulatory health authority for human therapeutic use

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Effects of ME3 on the proliferation, invasion and metastasis of pancreatic cancer cells through epithelial-mesenchymal transition