Przedkliniczne dane toksykologiczne: Badania toksycznoci ostrej i podostrej u szczurw nie ujawniy adnej miertelnoci ani istotnej toksycznoci narzdowej, nawet przy dawkach znacznie przekraczajcych dawki terapeutyczne (do 100-krotnoci dawki skutecznej)
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Hematologic disorders like chronic myelogeneous leukemia, promyelocytic leukemia, polycythemia vera, and hypereosinophilic syndrome can present as elevated serum blood levels of vitamin B12, which is also known clinically as serum cobalamin, note the authors of a 2013 research review published in the journal Clinical Biochemistry

One study showed that anise seed extract exhibited powerful antidepressant properties in mice and was as effective as a common prescription medication used to treat depression ( Whats more, in another study in 107 people, taking 3 grams of anise seed powder three times daily was effective at reducing symptoms of postpartum depression ( Similarly, in a four-week study in 120 people, taking a capsule with 200 mg of anise oil three times daily significantly decreased symptoms of mild to moderate depression, compared to a control group ( Summary Human and animal studies reveal that anise seed may help reduce symptoms of depression and may be as effective as some types of antidepressants
However, a placebo-controlled trial in 769 patients with MCI found that the same dosage of vitamin E did not affect the probability of progression from MCI to AD over a three-year period (108)