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Common Side Effects Gastrointestinal (additive): Nausea, vomiting, diarrhea, constipation and reduced appetite are the most common events and are amplified by stacking two agents that act on gut motility the dominant adverse-event category in REDEFINE [1] [2]

Dihexa (full name: N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is technically a peptidomimetica small molecule designed to mimic peptide binding activity while having improved stability and bioavailability compared to peptides

All code used for the current analysis and figure creation, alongside copies of supplementary figures, can be found here

The main difference is the presence of KPV in Klow

This approach leads to a reduction in food intake, delayed gastric emptying, and modulation of glucagon secretion