glutathione vs n acetylcysteine Mechanism of action and summary of N-acetylcysteine effects in Glutathione vs. NAC: An Expert

doi: 10.1016/j.biopha.2020.110234

Mango Almost all of us look forward to the summer for mangoes

Discovered in 2015 by Changhan David Lee and Pinchas Cohen at USC, MOTS-c is encoded in the 12S rRNA region of the mitochondrial genomemaking it one of a small but growing family of mitochondrial-derived peptides (MDPs) that challenge the longstanding view of mitochondria as passive energy factories.1 This discovery sheds new light on mitochondria and positions them as active regulators of metabolism. Changhan David Lee, Assistant Professor of Gerontology, USC Leonard Davis School12 The Exercise Connection Human studies show that circulating endogenous MOTS-c levels increase approximately 1.6-fold during exercise and remain elevated about 1.5-fold post-exercise before returning to baseline after roughly four hours.13 This temporal profile suggests MOTS-c functions as an exercise-induced mitokinea signaling molecule released by mitochondria in working muscles that communicates metabolic status to the rest of the body

In summary, the regulatory role of mitophagy is not simply "beneficial" or "detrimental", but a bidirectional regulatory process co-regulated by multiple factors

Glutathione can raise glutamate levels in the brain of some sensitive individuals