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3.3.2 Cortisol Cortisol, a glucocorticoid hormone associated with stress, usually increases during fasting to maintain glucose homeostasis through mechanisms such as gluconeogenesis and increased fat utilization [44]

Patients can choose a time in a day to use the dosage on an empty stomach

In addition, given the inherent day-to-day variability in function in the frail target population as well as the presence of a host of concomitant conditions, the appropriate patient population to be studied remains to be defined, and demonstration of clinically meaningful efficacy may be difficult

MMWR Surveill Summ