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In the case of alcohol the mechanism is well described: ethanol metabolism involving the CYP2E1 enzyme releases free radicals, and these reduce the level of reduced glutathione in the liver (Lieber, Drug Metabolism Reviews 2004, PMID 15554233)

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These findings, in line with several recent studies reporting the protective effects of statins in various kidney diseases [42,43,44,45], underscore the critical role of lipid metabolic dysregulation in CaOx-induced renal injury and suggest that pharmacological modulation of lipid metabolism may serve as a complementary strategy to targeting the PRMT1/UBE2m axis

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