Furthermore, excessive activation of mTOR inhibits autophagy during spermatogenesis, affecting the clearance of defective cells and the homeostasis of the intracellular environment, which in turn impacts sperm production [234,235,236]
Betaine, by restoring the methylation potential and normalizing the activities of the three methyltransferases, mitigates or eliminates these defects [23,81,82,90,91,92]
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The mimic antigens that induce disease may vary in different uveitis entities (103)