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doi: 10.3389/fphys.2026.1747210 Received 15 November 2025 Revised 01 February 2026 Accepted 10 February 2026 Published 25 March 2026 Volume 17 - 2026 Edited by Anala Ale, CONICET Santa Fe, Argentina Reviewed by Da Sun, Wenzhou University, China Rosa Bonaventura, National Research Council (CNR), Italy Muhammad Farhan Khan, Gomal University, Pakistan Updates Copyright 2026 Wickramasinghe and Ruvinda

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One explanation for this difference could be the varying pathophysiological mechanisms of depression between adults and adolescents (178, 179)