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Inhibits the response to interleukin-2 (IL-2)
It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting
Bafilomycin A1 (BafA1) is a specific and reversible inhibitor of vacuolar H+-ATPase (V-ATPase) with IC50 values of 4-400 nmol/mg
Proteins synthesized in the cytoplasm are directed to the ER
Adherent mammalian cells are sensitive to concentrations of 2 to 5 µg/ml
BAFF, Soluble (human) (60-mer) (rec.) (highly active) CD40L Inhibits the response to interleukin-2BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF R. BAFF is a master
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